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ACTN3 (rs1815739) GENİ İLE DARBEYE BAĞLI OLMAYAN SPOR YARALANMALARI İLİŞKİSİNİN İNCELENMESİ

Yıl 2023, Cilt: 21 Sayı: 4, 145 - 157, 30.12.2023
https://doi.org/10.33689/spormetre.1290017

Öz

Günümüz dünyasında sporun artan popülaritesi ve sporcuların performans limitlerinin ötesine geçme isteği beraberinde birtakım sorunları gündeme getirmiştir. Bu sorunlardan biri olan spor yaralanmaları, spora ayrılan zamanın kaybolması ile sonuçlanan multifaktöriyel özelliğe sahip olumsuz bir durumdur. Spor yaralanmalarının oluş mekanizmaları dikkate alındığında, içsel ve dışsal birçok faktörün bu fenomen üzerinde önemli etkilere sahip olduğu görülmektedir. Bu faktörlerden biri olmaya aday genetik, sporcuları yumuşak doku yaralanmalarına karşı daha duyarlı hâle getirebilmektedir. Derleme, bugüne kadar ACTN3 rs1815739 gen polimorfizmi ve spor yaralanmaları ile ilgili internet veri tabanına kayıtlı çalışmaların değerlendirmesini içermektedir. ACTN3 rs1815739 gen polimorfizmi, kaslarda aktin filamentlerinin Z diskine bağlanmasını sağlayan alfa aktinin 3 proteinini kodlamaktadır. Aktin miyofilamentleri, kas fibrillerinin kasılma fonksiyonunda önemli bir göreve sahiptir. ACTN3 geninin kodladığı alfa aktinin proteini, kan ve kasdaki seviyeye bağlı olarak kas morfolojisini etkileyebilmektedir. Sonuç olarak, ACTN3 rs1815739 gen polimorfizmindeki genotip ve aleller darbeye bağlı olmayan kas yaralanmalarının mekanizmasını önemli ölçüde değiştirebilmektedir.

Kaynakça

  • Al-Mayah, A. (2018). Biomechanics of Soft Tissues. 1st ed. USA: CRC Press; Milton, MA.
  • Almeida, K. Y., Cetolin, T., Marrero, A. R., Junior, A. S., Mohr, P., & Kikuchi, N. (2022). A Pilot study on the prediction of non-contact muscle injuries based on ACTN3 R577X and ACE I/D polymorphisms in professional soccer athletes. Genes (Basel), 13(11), 2-12. doi: 10.3390/genes13112009
  • Argut, K. S., & Çelik, D. (2018). Genç sporcularda spora bağlı yaralanmalara neden olan faktörler. Spor Bilimleri Araştırmaları Dergisi, 3(1), 122-127.
  • Arıkan, G., & Çimen, E. (2020). Üniversite adaylarının spor yaralanma kaygı düzeylerinin incelenmesi. Eurasian Research in Sport Science, 5(2), 118-127.
  • Artells, R., Pruna, R., Dellal, A., & Maffulli, N. (2016). Elastin: a possible genetic biomarker for more severe ligament injuries in elite soccer: A pilot study. Muscles Ligaments Tendons Journal, 6(2), 188–192. doi: 10.11138/mltj/2016.6.2.188
  • Baltazar-Martins, G., Gutiérrez-Hellín, J., Aguilar-Navarro, M., Ruiz-Moreno, C., Moreno-Pérez, V., López-Samanes, Á., . . . Coso, J. D. (2020). Effect of ACTN3 genotype on sports performance, exercise-induced muscle damage, and injury epidemiology. Sports (Basel), 8(7), 2-12. doi: 10.3390/sports8070099
  • Brazier, J., Antrobus , M., Stebbings, G. K., Day, S. H., Heffernan, S. M., Cross, M. J., & Williams, A. G. (2019). Tendon and ligament injuries in elite rugby: The Potential genetic influence. Sports (Basel), 7(6), 2-27. doi: 10.3390/sports7060138
  • Budak, H., Sanioğlu, A., Keretli, Ö., Durak, A., & Öz, B. (2020). Spor yaralanmasının kaygı üzerindeki etkileri. Kilis 7 Aralık Üniversitesi Beden Eğitimi ve Spor Bilimleri Dergisi, 4(1), 38-47.
  • Bulğay, C., Çetin, E., Orhan, Ö., & Ergün, M. A. (2020). Koşucularda ACTN3 ve ACE genlerinin spotif performansa etkisi. İnönü Üniversitesi, Beden Eğitimi ve Spor Bilimleri Dergisi, 7(1), 1-12.
  • Can, O. (2020). Ön çapraz bağ rüptürünün moleküler ve anatomopatolojik temelinin araştırılması.Yayınlanmamış uzmanlık tezi, Sivas Cumhuriyet Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı.
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  • Clarkson, P. M., Hoffman, E. P., Zambraski, E., Gordish-Dressman, H., Kearns, A., Hubal, M., . . . Devaney, J. M. (2005). ACTN3 and MLCK genotype associations with exertional muscle damage. Journal of Applied Physiology, 99, 564-569. doi:10.1152/japplphysiol.00130.2005
  • Clos, E., Pruna, R., Lundblad, M., Artells, R., & Caussa, J. E. (2019). ACTN3 single nucleotide polymorphism is associated with non-contact musculoskeletal soft-tissue injury incidence in elite professional football players. Knee Surgery, Sports Traumatology, Arthroscopy, 27(12), 4055-4061. doi: 10.1007/s00167-019-05381-x
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INVESTIGATION OF THE RELATIONSHIP BETWEEN ACTN3 (rs1815739) GENE AND NON-CONTACT SPORTS INJURIES

Yıl 2023, Cilt: 21 Sayı: 4, 145 - 157, 30.12.2023
https://doi.org/10.33689/spormetre.1290017

Öz

In today's world, the increasing popularity of sports and the desire of athletes to go beyond the performance limits have brought with them a number of problems. Sports injuries, one of these problems, is a negative condition with a multifactorial feature that results in the loss of time allocated to sports. When the mechanisms of occurrence of sports injuries are considered, it is seen that many internal and external factors have significant effects on this phenomenon. Genetics, which is a candidate for one of these factors, may make athletes more susceptible to soft tissue injuries. The review includes an evaluation of the studies recorded to date in the online database on ACTN3 rs1815739 gene polymorphism and sports injuries. The ACTN3 rs1815739 gene polymorphism encodes the alpha actin 3 protein that enables actin filaments in muscles to bind to the Z disc. Actin myofilaments have an important role in the contractile function of muscle fibrils. The alpha actin protein encoded by the ACTN3 gene can affect muscle morphology depending on the level in the blood and muscle. As a result, genotypes and alleles in the ACTN3 rs1815739 gene polymorphism can significantly alter the mechanism of non-contact muscle injuries.

Kaynakça

  • Al-Mayah, A. (2018). Biomechanics of Soft Tissues. 1st ed. USA: CRC Press; Milton, MA.
  • Almeida, K. Y., Cetolin, T., Marrero, A. R., Junior, A. S., Mohr, P., & Kikuchi, N. (2022). A Pilot study on the prediction of non-contact muscle injuries based on ACTN3 R577X and ACE I/D polymorphisms in professional soccer athletes. Genes (Basel), 13(11), 2-12. doi: 10.3390/genes13112009
  • Argut, K. S., & Çelik, D. (2018). Genç sporcularda spora bağlı yaralanmalara neden olan faktörler. Spor Bilimleri Araştırmaları Dergisi, 3(1), 122-127.
  • Arıkan, G., & Çimen, E. (2020). Üniversite adaylarının spor yaralanma kaygı düzeylerinin incelenmesi. Eurasian Research in Sport Science, 5(2), 118-127.
  • Artells, R., Pruna, R., Dellal, A., & Maffulli, N. (2016). Elastin: a possible genetic biomarker for more severe ligament injuries in elite soccer: A pilot study. Muscles Ligaments Tendons Journal, 6(2), 188–192. doi: 10.11138/mltj/2016.6.2.188
  • Baltazar-Martins, G., Gutiérrez-Hellín, J., Aguilar-Navarro, M., Ruiz-Moreno, C., Moreno-Pérez, V., López-Samanes, Á., . . . Coso, J. D. (2020). Effect of ACTN3 genotype on sports performance, exercise-induced muscle damage, and injury epidemiology. Sports (Basel), 8(7), 2-12. doi: 10.3390/sports8070099
  • Brazier, J., Antrobus , M., Stebbings, G. K., Day, S. H., Heffernan, S. M., Cross, M. J., & Williams, A. G. (2019). Tendon and ligament injuries in elite rugby: The Potential genetic influence. Sports (Basel), 7(6), 2-27. doi: 10.3390/sports7060138
  • Budak, H., Sanioğlu, A., Keretli, Ö., Durak, A., & Öz, B. (2020). Spor yaralanmasının kaygı üzerindeki etkileri. Kilis 7 Aralık Üniversitesi Beden Eğitimi ve Spor Bilimleri Dergisi, 4(1), 38-47.
  • Bulğay, C., Çetin, E., Orhan, Ö., & Ergün, M. A. (2020). Koşucularda ACTN3 ve ACE genlerinin spotif performansa etkisi. İnönü Üniversitesi, Beden Eğitimi ve Spor Bilimleri Dergisi, 7(1), 1-12.
  • Can, O. (2020). Ön çapraz bağ rüptürünün moleküler ve anatomopatolojik temelinin araştırılması.Yayınlanmamış uzmanlık tezi, Sivas Cumhuriyet Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı.
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  • Clarkson, P. M., Hoffman, E. P., Zambraski, E., Gordish-Dressman, H., Kearns, A., Hubal, M., . . . Devaney, J. M. (2005). ACTN3 and MLCK genotype associations with exertional muscle damage. Journal of Applied Physiology, 99, 564-569. doi:10.1152/japplphysiol.00130.2005
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  • Doğgün, M. (2022). Spor branşına yönlendirmede genetik testlerin stratejik rolü. Türk Spor Bilimleri Dergisi, 5(2), 155-167. doi: 10.46385/tsbd.1050575
  • Eken, B. F., Sercan, C., Kaya, D., & Ulucan, K. (2018). Darbeye bağlı olmayan yumuşak doku yaralanmalarında moleküler yaklaşım. Avrasya Spor Bilimleri Araştırmaları, 3(1), 15-25. doi: 10.22396/ERISS.2018.32
  • Eken, B. F., Yılmaz, Ö. Ö., Polat, T., Aslan, B. T., & Ulucan, K. (2021). Türk futbolcularda alfa- aktinin-3 (ACTN3) ve anjiyotensin dönüştürücü enzim (ACE) polimorfizmleri atletik performans için bir biyobelirteç olabilir mi? Eurasian Research in Sport Science, 6(2), 147-159.
  • Eroğlu, O., & Zileli, R. (2015). Genetik faktörlerin sportif performansa etkisi. Uluslararası Spor, Egzersiz ve Antrenman Bilimi Dergisi, 1(1), 63-76. doi.org/10.18826/ijsets.65225
  • Feldmann, D., Bope, C. D., Patricios, J., Chimusa, E. R., Collins, M., & September, A. V. (2022). A whole genome sequencing approach to anterior cruciate ligament rupture–a twin study in two unrelated families. PLoS One, 17(10), 1-25. doi: 10.1371/journal.pone.0274354
  • Gibbon, A., Hobbs, H., Merwe, W. v., Raleigh, S. M., Cook, J., Handley, C. J., . . . September, A. V. (2017). The MMP3 gene in musculoskeletal soft tissue injury risk profiling: A study in two independent sample groups. Journal of Sports Sciences, 35(7), 655-662. doi: 10.1080/02640414.2016
  • Guo, R., Ji, Z., Gao, S., Aizezi, A., Fan, Y., Wang, Z., & Ning , K. (2022). Association of COL5A1 gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis based on 21 observational studies. Journal of Orthopaedic Surgery and Research, 17(1), 2-13. doi: 10.1186/s13018-022-03020-9
  • Gutiérrez-Hellín, J., Baltazar-Martins, G., Aguilar-Navarro, M., Ruiz-Moreno, C., Oliván, J., & Coso, J. D. (2021). Effect of ACTN3 R577X genotype on injury epidemiology in elite endurance runners. Genes, 12(1), 2-9. doi: 10.3390/genes12010076
  • Henrique, J. S., Braga, P. L., Almeida, S. S., Nunes, N. S., Benfato, I. D., Arida, R. M., . . . Silva, S. G. (2022). Effect of the ACTN-3 gene polymorphism on functional fitness and executive function of elderly. Frontiers in Aging Neuroscience, 14, 1-8. doi: 10.3389/fnagi.2022.943934
  • İlgün, F., Günay, V., Yıldırım, S., & Cerit, M. (2020). Atletik performans genleri ve atletik yeteneğin belirlenmesine ilişkin yaklaşımlar. TURAN-SAM Uluslararası Bilimsel Hakemli Dergisi, 12(48), 166-174. doi.org/10.15189/1308-8041
  • Jacob, Y., Anderton , R. S., Wilkie, J. L., Rogalski , B., Laws, S. M., Jones , A., . . . Hart, N. H. (2022). Genetic variants within NOGGIN, COL1A1, COL5A1, and IGF2 are associated with musculoskeletal injuries in elite male Australian Football League players: A preliminary study. Sports Medicine Open, 18(1), 2-14. doi: 10.1186/s40798-022-00522-y
  • Jarvinen, T. A., Kannus, P., Maffulli, N., & Khan, K. M. (2005). Achilles tendon disorders: Etiology and epidemiology. Foot and Ankle Clinics, 10(2), 255-266. doi:10.1016/j.fcl.2005.01.013
  • John, R., Dhillon, M. S., & Dhillon, S. (2020). Genetics and the elite athlete: Our understanding in 2020. Indian Journal of Orthopaedics, 54(3), 256-263. doi: 10.1007/s43465-020-00056-z
  • Kahya, S., Uğurtay, E., & Eliöz, M. (2022). Spor genetiği: Yumuşak doku yaralanmaları ve gen ile ilgili yaplan çalışmalar. L. Ceylan (Ed.), Spor Bilimlerine Kuramsal Bakış (19-39). Ankara: Gazi.
  • Kaman, T., Kapıcı, S., Sercan, C., Konuk, M., & Ulucan, K. (2017). Türk Milli Bisikletçilerde Alfa- Aktinin-3 R577X Polimorfizm. Marmara Üniversitesi Spor Bilimleri Dergisi, 2(1), 41-47. doi: 10.22396/sbd.2017.24
  • Kambouris, M., Ntalouka, F., Ziogas, G., & Maffulli, N. (2012). Predictive genomics DNA profiling for athletic performance. Recent Patents on DNA & Gene Sequences, 6(3), 229-239.
  • Karayılan, Ş. Ş., Dönmez, G., Babayeva, N., Yargıç, M. P., Korkusuz, F., & Doral, M. N. (2013). Spor yaralanmaları ve genetik. Spor Hekimliği Dergisi, 48, 139-146.
  • Karayol, M., & Eroğlu, Y. S. (2020). Takım ve bireysel sporlarla ilgilenen sporcuların spor yaralanması kaygı durumlarının incelenmesi. Spor Eğitim Dergisi, 4(1), 137-144.
  • Karip, B., & Balcıoğlu, H. A. (2021). Egzersiz fizyolojisi bağlamında musküler plastisite. Gaziantep Üniversitesi Spor Bilimleri Dergisi, 6(3), 266-278.
  • Keser, İ. (2021). Spor genetiği: Mağradan spor salonuna DNA yolculuğu. Ankara: Çukurova Nobel Tıp.
  • Khoury, L. E., Ribbans, W. J., & Raleigh, S. M. (2016). MMP3 and TIMP2 gene variants as predisposing factors for Achilles tendon pathologies: Attempted replication study in a British case-control cohort. Meta Gene, 9, 52-55. doi.org/10.1016/j.mgene.2016.03.007
  • Kim, J. H., Jung, E. S., Kim, C.-H., Youn, H., & Kim, H. R. (2014). Genetic associations of body composition, flexibility and injury risk with ACE, ACTN3 and COL5A1 polymorphisms in Korean ballerinas. Journal of Exercise Nutrition and Biochemistry, 18(2), 205-214. doi: 10.5717/jenb.2014.18.2.205
  • Kozacı, N., & Avcı, M. (2020). Acil serviste odaklanmış kas-iskelet ultrasonografisi ile kas yaralanmalarının tanısı: Bir olgu sunumu. Anatolian Journal of Emergency Medicine, 3(2), 58-61.
  • Kumagai, H., Miller, B., Kim, S.-J., Leelaprachakul, N., Kikuchi, N., Yen, K., & Cohen, P. (2023). Novel insights into mitochondrial DNA: Mitochondrial microproteins and mtDNA variants modulate athletic performance and age-related diseases. Genes (Basel), 14(2), 2-18. doi: 10.3390/genes14020286
  • Lv, Z.-T., Gao, S.-T., Cheng, P., Liang, S., Yu, S.-Y., Yang, Q., & Chen, A.-M. (2018). Association between polymorphism rs12722 in COL5A1 and musculoskeletal soft tissue injuries: a systematic review and meta-analysis. Oncotarget, 9(20), 15365–15374. doi: 10.18632/oncotarget.23805
  • Maffulli, N., Margiotti, K., Longo, U. G., Loppini, M., Fazio, V. M., & Denaro, V. (2013). The genetics of sports injuries and athletic performance. Muscles Ligaments Tendons Journal, 3(3), 173-189.
  • Mangine, R., Tersak, J., Palmer, T., Hill-Lindsay, A., Patton, B., Eifert-Mangine, M., . . . Colosimo, A. J. (2023). The longitudinal neurophysiological adaptation of a division I female lacrosse player following anterior cruciate rupture and repair: A case report. International Journal of Sports Physical Therapy, 18(2), 467-476. doi: 10.26603/001c.73179
  • Massidda, M., Corrias, L., Scorcu, M., Vona, G., & Calò, M. C. (2012). ACTN-3 and ACE genotypes in elite male Italian athletes. Anthropological Review, 75, 51-59. doi: 10.2478/v10044-012-0004-4
  • Mokone, G. G., Schwellnus, M. P., Noakes, T. D., & Collins, M. (2005). The COL5A1 gene and Achilles tendon pathology. Scandinavian Journal of Medicine & Science in Sports, 16, 19-26. doi: 10.1111/j.1600-0838.2005.00439.x
  • Moorchung, N., Puri, B., Bhatti, V., Lahareesh, B. L., Singh, S. P., & Sitaram, W. T. (2019). In the search of a ‘fitness gene’: an analysis of ACTN gene polymorphisms in serving soldiers. Medical Journal Armed Forces India, 75(3), 246-250. doi: 10.1016/j.mjafi.2019.07.004
  • Moreno, V., Areces, F., Ruiz-Vicente, D., Ordovás, J. M., & Coso, J. D. (2020). Influence of the ACTN3 R577X genotype on the injury epidemiology of marathon runners. Plos One, 15(1), 1-11. doi: 10.1371/journal.pone.0227548
  • Naureen, Z., Perrone, M., Paolacci , S., Maltese, P. E., Dhuli , K., Kurti , D., . . . Bertelli, M. (2020). Genetic test for the personalization of sport training. Acta Biomedica, 91(13-S), 2-15. doi: 10.23750/abm.v91i13-S.10593
  • Nguyen, T.-N., Tho, M.-C. H., & Dao, T.-T. (2020). A systematic review of real-time medical simulations with soft-tissue deformation: Computational approaches, interaction devices, system architectures, and clinical validations. Applied Bionics and Biomechanics 2020, 1-30. doi: 10.1155/2020/5039329
  • Nisam, A., & Raj, Y. L. (2018). Sports injuries, types and prevention. International Journal of Physiology, Nutrition and Physical Education, 3(1), 1353-1356.
  • Onori , M. E., Pasqualetti , M., Moretti , G., Canu , G., Paolis , G. D., Baroni , S., . . . Urbani, A. (2022). Genetics and sport injuries: New perspectives for athletic excellence in an Italian court of rugby union players. Genes, 13(6), 2-7. doi.org/10.3390/genes13060995
  • Özaltın, G. E., Talu, B., & Öktem, U. (2023). Functional outcomes of motor learning interventions in anterior. Archives Medical Review Journal, 32(1), 33-41. doi:10.17827/aktd.1169499
  • Özkan, Ö. C., & Öztürk, B. Y. (2018). Ön çapraz bağ yaralanmaları ve tedavisi. Boğaziçi Tıp Dergisi, 5(2), 72-75. doi: 10.15659/bogazicitip.18.10.987
  • Petersen, J., & Hölmich, P. (2005). Evidence based prevention of hamstring injuries in sport. British Journal of Sports Medicine, 39(6), 319-323. doi: 10.1136/bjsm.2005.018549
  • Pickering, C., & Kiely, J. (2017). ACTN3: More than Just a gene for speed. Sec. Exercise Physiology, 18(8), 1-9. doi: 10.3389/fphys.2017.01080
  • Pruna, R., Artells, R., Ribas, J., Montoro, B., Cos, F., Muñoz, C., . . . Maffulli, N. (2013). Single nucleotide polymorphisms associated with non-contact soft tissue injuries in elite professional soccer players: influence on degree of injury and recovery time. BMC Musculoskeletal Disorders, 14(221), 2-7. doi: 10.1186/1471-2474-14-221
  • Ramos, B. R., Mendes, N. D., Tanikawa, A. A., Amador, M. A., Santos, N. P., Santos, S. E., . . . Silva, M. G. (2016). Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. BMC Pregnancy and Childbirth, 16(30), 2-11. doi: 10.1186/s12884-016-0823-1
  • Ribbans, W. J., September, A. V., & Collins, M. (2022). Tendon and ligament genetics: How do they contribute to disease and injury? A narrative review. Life (Basel), 12(5), 2-36. doi: 10.3390/life12050663
  • September, A. V., & Posthumus, M. (2012). Application of genomics in the prevention, treatment and management of achilles tendinopathy and anterior cruciate ligament ruptures. Bentham Science, 6(3), 216-223. doi: 10.2174/187221512802717358
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  • Subak, G. E., Özdemir, F. Ş., & Müniroğlu, R. S. (2017). Sporcuların başarısında genetik faktörlerin önemi. Spormetre, 15(3), 109-118.
  • Şanlısoy, F., Altıntaş, N., Büyükyazı, G., & Candan, N. (2011). Ege bölgesi elit sporcularının ACTN3 R577X genotip dağılımının araştırılması. Cumhuriyet Tıp Dergisi, 33(2), 153-159.
  • Türkmen, A., Dündar, G. Y., & Akyolcu, N. (2020). Acil servislerde görülen ortopedik travmalar ve hemşirelik bakımı. JAREN, 6(2), 375-80. doi:10.5222/jaren.2020.88700
  • Vancini, R. L., Pesquero, J. B., Fachina, R. J., Andrade, M. d., Borin, J. P., Montagner, P. C., & Lira, C. A. (2014). Genetic aspects of athletic performance: the African runners phenomenon. Open Access Journal of Sports Medicine, 5, 123—127. doi.org/10.2147/OAJSM.S61361
  • Varillas-Delgado, D., Gutierrez-Hellín, J., & Maestro, A. (2023). Genetic profle in genes associated with sports injuries in elite endurance athletes. International Journal of Sports Medicine, 44(1), 64–71. doi: 10.1055/a-1917-9212
  • Yalıman, A. (2017). Yumuşak doku yaralanmalarında yaklaşım ve tedavide oral nonsteroid antiinflamatuvar ilaçların yeri. Klinik Tıp Aile Hekimliği Dergisi, 9(6), 7-12.
  • Yang, S., Lin, W., Jia, M., & Chen, H. (2023). Association between ACE and ACTN3 genes polymorphisms and athletic performance in elite and sub-elite Chinese youth male football players. PeerJ, 11, 1-21. doi: 10.7717/peerj.14893
Toplam 72 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Spor Hekimliği
Bölüm Derleme
Yazarlar

Sedat Kahya 0000-0002-1169-2642

Erken Görünüm Tarihi 28 Aralık 2023
Yayımlanma Tarihi 30 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 21 Sayı: 4

Kaynak Göster

APA Kahya, S. (2023). ACTN3 (rs1815739) GENİ İLE DARBEYE BAĞLI OLMAYAN SPOR YARALANMALARI İLİŞKİSİNİN İNCELENMESİ. SPORMETRE Beden Eğitimi Ve Spor Bilimleri Dergisi, 21(4), 145-157. https://doi.org/10.33689/spormetre.1290017

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