Review Article
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Effects of Caffeine on Physical and Cognitive Performance: A Review

Year 2022, Volume: 1 Issue: 1, 1 - 20, 05.12.2022

Raci Karayiğit Muhammed Uygar Sertkaya

Abstract

Caffeine is one of the most consumed nutritional ergogenic supplements by athletes. In the literature, it is now widely accepted that caffeine taken 60 minutes before exercise improves performance. There are different methods of caffeine intake; Caffeinated gum, coffee, anhydrous and gel forms are among the most commonly used. Generally, the ergogenic effect sizes of different forms of caffeine consumption do not differ significantly. The effectiveness of caffeine doses of 3-6 mg/kg has been proven. However, in recent years, doses <3 mg/kg have also begun to be investigated, and some studies have reported positive effects. In addition, it can be stated from the literature that there is no difference in the responses of male and female athletes to caffeine. It can be argued that the distribution of the CYP1A2 gene allele (AA, AC), which is responsible for the metabolism of caffeine, may change the physical and cognitive responses to caffeine and that athletes should consider this factor.

Keywords

Coffee athletic ergogenic supplement

References

  • 1. Aguiar A.S., Speck, A.E., Canas, P.M., Cunha, R.A. (2020). Neuronal adenosine A2A receptors signal ergogenic effects of caffeine. Scientific Reports, 10, 13414.
  • 2. Akça, F., Aras, D., Arslan, E. (2018). Kafein, etki mekanizmaları ve fiziksel performansa etkileri. Spormetre, 16(1), 1-12.
  • 3. Algrain Haya, A.T.R.M., Carrillo, A.E., Ryan, E.J., Chuk-ho, K., Lettan, R.B., Ryan, E.J. (2016). The effects of a polymorphism in the cytochrome P450 CYP1A2 gene on performance enhancement with caffeine in recreational cyclists. Journal of Caffeine Research, 6(1), 34-39.
  • 4. Anderson, D.E., German, R.E., Harrison, M.E., Bourassa, K.N., Taylor, C.E. (2020). Real and perceived effects of caffeine on sprint cycling in experienced cyclists. Journal of Strength and Conditioning Research, 34(4), 929-933.
  • 5. Apostolidis, A., Mougios, V., Smilios, I., Frangous, M., Hadjicharalambou, M. (2020). Caffeine supplementation is ergogenic in soccer players independent of cardiorespiratory or neuromuscular fitness levels. Journal of the International Society of Sports Nutrition, 17, 31.
  • 6. Bayraktar, F., Taşkıran, A. (2019). Kafein tüketimi ve atletik performans. Journal of Health and Sport Sciences, 2(2), 24-33.
  • 7. Bayram, H.M., Ozturkcan, S.A. (2020). Sporcularda ergojenik destekler. Türkiye Klinikleri Sağlık Bilimleri Dergisi, 5(3), 641-652.
  • 8. Beaumont, R., Cordery, P., Funnell, M., Mears, S., James, L., Watson, P. (2017). Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine. Journal of Sports Sciences, 35(19), 1920-1927.
  • 9. Bell, D.G., Mclellan, T.M. (2002). Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers. Journal of Applied Physiology. 93(4), 1227-1234.
  • 10. Bottoms, L., Greenhalgh, A., Gregory, K. (2013). The effect of caffeine ingestion on skill maintenance and fatigue in epee fencers. Journal of Sports Sciences, 31(10), 1091-9.
  • 11. Burke, L.M. (2017). Practical issues in evidence-based use of performance supplements: supplement interactions, repeated use and individual responses. Sports Medicine, 47, 79-100.
  • 12. Cairns, S.P., Hing, W.A., Slack, J.R., Mills, R.G., Loiselle, D.S. (1997). Different effects of raised [K+] on membrane potential and contraction in mouse fast and slow-twitch muscle. American Journal of Physiology Cell Physiology, 273,598-611.
  • 13. Chia, J.S., Barrett, L.A., Chow, J.Y., Burns, S.F. (2017). Effects of caffeine supplementation on performance in ball games. Sports Medicine, 47(12), 2453-2471.
  • 14. Childs, E., Hohoff, C., Deckert, J., Xu, K., Badner, J., With, H. (2008). Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology, 33(12), 1694-1702.
  • 15. Christensen, P.M., Shirai, Y., Ritz, C., Nordborg, N.B. (2017). Caffeine and bicarbonate for speed. A meta-analysis of legal supplements potential for improving intense endurance exercise performance. Frontiers in Physiology, 8, 240.
  • 16. Christopher, L., Hendy, A., Vanderwesthuizen, D., Teo, W.P. (2018). The modulation of corticospinal excitability and inhibition following acute resistance exercise in males and females. European Journal of Sport Science, 18(7), 984-993.
  • 17. Clarke N, Baxter, H., Fajemilua, E., Jones, V., Oxford, S., Richardson, D.L., Wyatt, C., Mundy, P. (2016). Coffee and caffeine ingestion have little effect on repeated sprint cycling in relatively untrained males. Sports. 4, 45.
  • 18. Clarke, N.D., Richardson, D.L., Thie, J., Taylor, R. (2018). Coffee ingestion enhances 1-mile running race performance. Nutrients, 13, 789-794.
  • 19. Clarke, N.D., Kirwan, N.A., Richardson, D.L. (2019). Coffee ingestion improves 5 km cycling performance in men and women by a similar magnitude. Nutrients, 11, 2575.
  • 20. Clarke, N.D., Richardson, D.L. (2016). Effect of coffee and caffeine ingestion on resistance exercise performance. Journal of Strength and Conditioning Research. 30(10), 2892-2900.
  • 21. Cornelis, M.C. (2019). The impact of caffeine and coffee on human health. Nutrients, 11, 416.
  • 22. Cruz, R.S.D.O., De Aguiar, R.A., Turnes, T., Guglielmo, L.G.A., Beneke, R., Caputo, F. (2015). Caffeine affects time to exhaustion and substrate oxidation during cycling at maximal lactate steady state. Nutrients, 7, 5254-5264.
  • 23. Del Coso, J., Lara, B., Ruiz-Moreno, C., Salinero, J.J. (2019). Challenging the myth of non-response to the ergogenic effects of caffeine ingestion on exercise performance. Nutrients, 11, 732.
  • 24. Denoeud, F., Carretero-Paulet, L., Dereeper, A., Droc, G., Guyot, R., Pietrella, M., Aury, J.M. (2014). The coffee genome provides insight into the convergent evolution of caffeine biosynthesis. Science, 345(6201), 1181-1184.
  • 25. Doepker, C., Wikoff, D. (2018). Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Nutrients, 10(10), 1536.
  • 26. Duncan, M.J., Dobell, A.P., Caygill, C.L., Eyre, E., Tallis, J. (2019). The effect of acute caffeine ingestion on upper body anaerobic exercise and cognitive performance. European Journal of Sport Science, 19(1), 103-111.
  • 27. Dunican, I.C., Higgins, C.C., Jones, M.J., Clarke, M.W., Murray, K., Dawson, B., Caldwell, J.A., Halson, S.L.,
  • 28. Eastwood, P.R. (2018). Caffeine use in a super rugby game and its relationship to post – game sleep. European Journal of Sport Science, 18(4), 513-523.
  • 29. El Yacoubi, M., Ledent, C., Menard, J.F., Parmentier, M., Costentin, J., Vaugeois, J.M. (2000). The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A (2A) receptors. British Journal of Pharmacology, 129(7), 1465-1473.
  • 30. Ferre, S. (2016). Mechanisms of the psychostimulant effects of caffiene: implications for substance use disorder. Psychopharmacology, 233(10), 1963-1979.
  • 31. Ferreira, T.T., Farrias Da Silva, J.V., Bueno, N.B. (2020). Effects of caffeine supplementation on muscle endurance, maximum strength, and perceived exertion in adults submitted to strength training: a systematic review and meta-analyses. Critical Reviews in Food Science and Nutrition, 61(15), 2587-2600.
  • 32. Filip, A., Wilk, M., Krzytofik, M., Del Coso, J. (2020). Inconsistency in the ergogenic effect of caffeine in athletes who regularly consume caffeine: is it due to the disparity in the criteria that defines habitual caffeine intake?. Nutrients, 12, 1087.
  • 33. Filip-Stachnik, A., Wilk, M., Krzytofik, M., Lulinska, E., Tufano, J.J., Zajac, A., Stastny, P., Del Coso, J. (2021). The effects of different doses of caffeine on maximal strength and strength-endurance in women habituated to caffeine. Journal of International Society of Sports Nutrition, 18(1), 25.
  • 34. Foskett, A., Ali, A., Gant, N. (2009). Caffeine enhances cognitive function and skill performance during simulated soccer acitivity. International Journal of Sports Nutrition and Exercise Metabolism, 19(4), 410-423.
  • 35. Gonçalves, L.S., Painelli, V.S., Yamaguchi, G., Oliveira, L.F., Saunders, B., Silva, R.P., Maciel, E., Artioli, G.G., Roschel, H., Gualano, B. (2017). Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. Journal of Applied Physiology, 123(1), 213-220.
  • 36. Grgic J, Grgic I, Pickering C, Schoenfeld Bj, Bishop Dj, Pedisic Z (2019). Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. British Journal of Sports Medicine, 11: 681-688.
  • 37. Grgic, J., Mikulic, P. (2020). Acute effects of caffeine supplementation on resistance exercise, jumping, and wingate performance: no influence of habitual caffeine intake. European Journal of Sport Science, 21(8), 1165-1175.
  • 38. Graham, T.E. (2001). Caffeine and exercise: metabolism, endurance and performance. Sports medicine, 31(11), 785-807.
  • 39. Guest, N., Corey, P., Vesconi, J., El-Sohemy, A. (2018). Caffeine, CYP1A2 genotype, and endurance performance in athletes. Medicine and Science in Sport and Exercise, 50(8), 1570-1578.
  • 40. Guest, N.S., Vandusseldrop, T.A., Nelson, M.T., Grgic, J., Schoenfeld, B.J., Jenkinds, N.D.M., Arent, S.M., Antonio, J., Stout, J.R., Trexler, E.T., Smith-Ryan, A.E., Goldstein, E.R., Kalman, D.S., Campbell, B.I. (2021). International society of sport nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1.
  • 41. Hall, S., Desbrow, B., Anoopkumar-Dukie, S., Davey, A.K., Arora, D., Mcdermott, C., Grant, G.D. (2015). A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression. Food Research International, 76(3), 626-636.
  • 42. Hunter, S.K. (2016). The relevance of sex differences in performance fatigability. Medicine and Science in Sports and Exercise, 48(11), 2247-2256.
  • 43. Irwin, C., Desbrow, B., Ellis, A., O’Keeffe, B., Grant, G., Leveritt, M. (2011). Caffeine withdrawal and high-intensity endurance cycling performance. Journal of Sports Sciences. 29(5), 509-515.
  • 44. Jeukendrup, A.E. (2017). Periodized nutrition for athletes. Sports Medicine, 47, 51-63.
  • 45. Kaçoğlu, C. (2019). Adölesan kız hentbolcularda, düşük doz kahve tüketiminin anaerobik performansa akut etkileri. Türkiye Klinikleri Spor Bilimleri Dergisi, 11(3), 97-107.
  • 46. Kamimori, G.H., Karyekar, C.S., Otterstetter, R., Cox, D.S., Balkin, T.J., Belenky, G.L., Eddington, N.D. (2002). The rate of absortion and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy vounteers. International Journal of Pharmaceutics, 234(1-2), 159-167.
  • 47. Kara, Z., Taşkın, H., Erkmen, N., Baştürk, D. (2019). Kafein takviyesinin kısa süreli yüksek yoğunluklu egzersize etkisi: kafein alım zamanı. Spor ve Performans Araştırmaları Dergisi, 10(1), 31-43.
  • 48. Karayigit, R., Naderi, A., Akça, F., Gomez Da Cruz, C.J., Sarshin, A., Yasli, B.C., Ersöz, G., Kaviani, M. (2021). Effects of different doses of caffeinated coffee on muscular endurance, cognitive performance and cardiac autonomic modulation in caffeine naive female athletes. Nutrients, 13, 2.
  • 49. Lara, B., Ruiz-Moreno, C., Salinero, J.J., Del Coso, J. (2019). Time course of tolerance to the performance benefits of caffeine. Plos One, 14(1), e0210275.
  • 50. Lara, B., Salinero, J.J., Giraldez-Costos, V., Del Coso, J. (2021). Similar ergogenic effect of caffeine on anaerobic performance in men and women athletes. European Journal of Nutrition, online ahead of print.
  • 51. Liebherman, H.R., Tharion, W.J., Shukitt-Hale, B., Speckman, K.L., Tulley, R. (2002). Effects of caffeine, sleep loss and stress on cognitive performance and mood during U.S. Navy Seal training. Psychopharmacology, 164(3), 250-261.
  • 52. Magkos, F., Kavarous, S.T. (2005). Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Critical Reviews in Food Science and Nutrition. 45(7-8), 535-562.
  • 53. Marcil, M., Karelis, A.D., Peronet, F., Gardier, P.F. (2005). Glucose infusion attenuates fatigue without sparing glycogen in rat soleus muscle during prolonged electrical stimulation in situ. European Journal of Applied Physiology, 93(5-6), 569-574.
  • 54. Martins, G.L., Guilherme, J.P.L.F., Ferreira, L.H.B., Souza-Junior, T.P., Lancha, A.H. (2020). Caffeine and exercise performance: possible directions for definitive findings. Frontiers in Sports and Active Living, 2, 574854.
  • 55. Mattson, M.P. (2012). Evolutionary aspects of human exercise-born to run purposefully. Ageing Research Reviews, 11(3), 347-352.
  • 56. Maughan, R.J., Burke, L.M., Dvorak, J., Larson-Meyer D.E., Peeling, P., Philips, S.M. (2018). IOC consensus statement: dietary supplements and the high-performance athlete. International Journal of Sport Nutrition and Exercise Metabolism, 28(2), 104-125.
  • 57. Mclellan, T.M., Kamimori, G.H., Voss, D.M., Tate, C., Smith, S.J. (2007). Caffeine effects on physical and cognitive performance during sustained operations. Aviation Space Environmental Medicine, 78(9), 871-877.
  • 58. Mclellan, T.M., Caldwell, J.A., Liebherman, H.R. (2016). A review of caffeine’s effects of cognitive, physical and occupational performance. Nueroscience&Biobehavioral reviews, 71, 294-312.
  • 59. Mielgo-Ayuso, J., Marques-Jimenez, D., Refoyo, I., Del Coso, J., Leon-Guereno, P., Calleja-Gonzalez, J. (2019). Effect of caffeine supplementation on sports performance based on differences between sexes: a systematic review. Nutrients, 11, 2313.
  • 60. Mohr, M., Nielsen, J.J., Bangsbo, J. (2011). Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation. Journal of Applied Physiology, 111(5), 1372-1379.
  • 61. Ogawa, N., Ueki, H. (2007). Clinical importance of caffeine dependence and abuse. Psychiatry Clin Neurosci, 61(3), 263-268.
  • 62. Ou-Yang, D.S., Huang, S.L., Wang, W. (2000). Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population. British Journal of Clinical pharmacology, 49(2), 145-151.
  • 63. Ryan, E.J., Kim, C.H., Fickes, E.J., Williamson, M., Muller, M.D., Barkley, J.E. (2013). Caffeine gum and cycling performance: a timing study. Journal of Strength and Conditioning Research, 27(1), 259-264.
  • 64. Pallares, J.G., Fernandez-Elias, V.E., Ortega, J.F., Munoz, G., Munoz-Guerra J., Mora-Rodriguez, R. (2013). Neuromuscular responses to incremental caffeine doses: performance and side effects. Medicine and Science in Sport and Exercise, 45(11), 2184-2192.
  • 65. Pataky, M.W., Womack, C.J., Saunders, M.J., Goffe, J.L., D’Lugos, A.C., El-Sohemy, A. (2016). Caffeine and 3-km cycling performance effects of mouth rinsing, genotype, and time of day. Scandinavian Journal of Medicine and Science in Sports, 26(6), 613-619.
  • 66. Pickering, C., Grgic, J. (2019). Caffeine and exercise: what next?. Sports Medicine, 49(7), 1007-1030.
  • 67. Pickering, C., Grgic, J. (2021). A time and a place: a framework for caffeine periodization throughout the sporting year. Nutrition, 82, 111046.
  • 68. Pickering, C., & Kiely, J. (2019). Do non-responders to exercise exist—and if so, what should we do about them?. Sports Medicine, 49(1), 1-7.
  • 69. Pontifex, K.J., Wallman, K.E., Dawson, B.T., Goodman, C. (2010). Effects of caffeine on repeated sprint ability, reactive agility time, sleep and next day performance. Journal of Sports Medicine and Physical Fitness, 50(4), 455-464.
  • 70. Ruiz-Moreno, C., Lara, B., Gutierrez-Hellin, J., Gonzalez-Garcia, J., Del Coso, J. (2020). Time course and magnitude of tolerance to the ergogenic effect of caffeine on the second ventilatory threshold. Life, 10(12), 343.
  • 71. Ryan Ej, Kım Ch, Fıckes Ej, Wıllıamson M, Muller Md, Barkley Je (2013). Journal of Strength and Conditioning Research, 27: 259-264.
  • 72. Sabblah, S., Dizon, D., Bottoms, L. (2015). Sex differences on the acute effects of caffeine on maximal strength and muscular endurance. Comperative Exercise Physiology, 11(2), 89-94.
  • 73. Salinero, J., Jimenez-Ormeno, E., Romero-Moraleda, B., Giraldez-Costas, V., Baltazar-Martins, G., Del Coso, J. (2019). More research is necessary to establish the ergogenic effect of caffeine in female athletes. Nutrients, 11, 1600.
  • 74. Shen, JG, Brooks, M.B., Cincotta, J., Manjourides, J.D. (2019). Establishing a relationship between the effect of caffeine and duration of endurance athletic time trial events: a systematic review and meta-analysis. Journal of Science and Medicine in Sport, 22(2), 232-238.
  • 75. Skinner, T.L., Desbrow, B., Arapova, J., Schaumberg, M.A., Osborne, J., Grant, G.D., Aanookumar-Dukie, S., Leveritt, M.D. (2019). Women experience the same ergogenic response to caffeine as men. Medicine and Science in Sport and Exercise, 51(6), 1195-1202.
  • 76. Southward, K., Rurtherfurd-Markwick, K.J., Ali, A. (2018). The effect of acute caffeine ingestion on endurance performance: a systematic review and meta-analysis. Sports Medicine, 48(8), 1913-1928.
  • 77. Spriet, L.L. (2014). Exercise and sport performance with low doses of caffeine. Sports Medicine, Suppl 2, 175-184.
  • 78. Stuart, G.R., Hopkins, W.G., Cook, C., Cairns, S.P. (2005). Multiple effects of caffeine on simulated high-intensity team-sport performance. Medicine and Science in Sports and Exercise, 37(11), 1998-2005.
  • 79. Taylor, C., Higham, D., Close, G.L., Morton, J.P. (2011). The effect of adding caffeine to postexercise carbohydrate feeding on subsequent high-intensity interval-running capacity compared with carbohydrate alone. International Journal of Sport Sutrition and Exercise Metabolism, 21(5), 410-416.
  • 80. Tepper, J.M., Wilson, C.J., Koös, T. (2008). Feedforward and feedback inhibition in neostriatal GABAergic spiny neurons. Brain Research Reviews, 58(2), 272-281.
  • 81. Thibault, V., Guillaume, M., Berthelot, G., El Helou, N., Schaal, J., Quinquis, L., Nassif, H., Tafflet, M., Escolano, S., Hermine, O. (2010). Women and men in sport performance: the gender gap has not evolved since 1983. Journal of Sports Science and Medicine, 9(2), 214-223.
  • 82. Trexler, E.T., Smith-Ryan, A.E., Roelofs, E.J., Hirsch, K.R., Mock, M.G. (2015). Effects of coffee and caffeine anhydrous on strength and sprint performance. European Journal of Sport Science. 16(6), 702-710.
  • 83. Ulucan, K., Sercan, C., Eken B.F., Ulgut, D., Erel, S. (2016). Spor genetiği ve ace gen ilişkisi. İnönü Üniversitesi Beden Eğitimi ve Spor Bilimleri Dergisi, 3(2), 26-34.
  • 84. Warren, G.L., Park, N.D., Maresca, R.D., Mckibans, K.I., Millard-Stafford, M.L. (2010). Effect of caffiene ingestioon muscular strength and endurance: a meta-alalysis. Medicine and Science in Sport and Science. 42(7), 1375-1387.
  • 85. Wilk, M., Filip, A., Krzsytofik, M., Maszczy, A., Zajac, A. (2019). The acute effect of various doses of caffeine on power output and velocity during the bench press exercise among athletes habitually using caffeine. Nutrients, 11, 1465.
  • 86. Womack, C.J., Saunders, M.J., Bechtel, M.K., Bolton, D.J., Martin, M., Luden, N.D. (2012). The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. Journal of International Society of Sport Nutrition, 9(1), 438-452.
  • 87. Van Thuyne, W., Delbeke, F.T. (2006). Distribution of caffeine levels in urine in different sports in relation to doping control before and after the removal of caffeine from the WADA doping list. International Journal of Sports Medicine, 27(9), 745-750.
  • 88. Yang, C., Franciosi, S., Brown, R.E. (2013). Adenosine inhibits the excitatory synaptic inputs to basal forebrain cholinergic, GABAergic, and parvalbumin neurons in mice. Frontiers in Neurology, 4, 77.
  • 89. Zhan, B., Liu, Y., Wang Xiaochun, W., Deng, Y., Zheng, X. (2020). Cognition and brain activation in response to various doses of caffeine: a near-infrared spectroscopy study. Frontiers in Psychology, 11, 1393.

Year 2022, Volume: 1 Issue: 1, 1 - 20, 05.12.2022

Raci Karayiğit Muhammed Uygar Sertkaya

Abstract

References

  • 1. Aguiar A.S., Speck, A.E., Canas, P.M., Cunha, R.A. (2020). Neuronal adenosine A2A receptors signal ergogenic effects of caffeine. Scientific Reports, 10, 13414.
  • 2. Akça, F., Aras, D., Arslan, E. (2018). Kafein, etki mekanizmaları ve fiziksel performansa etkileri. Spormetre, 16(1), 1-12.
  • 3. Algrain Haya, A.T.R.M., Carrillo, A.E., Ryan, E.J., Chuk-ho, K., Lettan, R.B., Ryan, E.J. (2016). The effects of a polymorphism in the cytochrome P450 CYP1A2 gene on performance enhancement with caffeine in recreational cyclists. Journal of Caffeine Research, 6(1), 34-39.
  • 4. Anderson, D.E., German, R.E., Harrison, M.E., Bourassa, K.N., Taylor, C.E. (2020). Real and perceived effects of caffeine on sprint cycling in experienced cyclists. Journal of Strength and Conditioning Research, 34(4), 929-933.
  • 5. Apostolidis, A., Mougios, V., Smilios, I., Frangous, M., Hadjicharalambou, M. (2020). Caffeine supplementation is ergogenic in soccer players independent of cardiorespiratory or neuromuscular fitness levels. Journal of the International Society of Sports Nutrition, 17, 31.
  • 6. Bayraktar, F., Taşkıran, A. (2019). Kafein tüketimi ve atletik performans. Journal of Health and Sport Sciences, 2(2), 24-33.
  • 7. Bayram, H.M., Ozturkcan, S.A. (2020). Sporcularda ergojenik destekler. Türkiye Klinikleri Sağlık Bilimleri Dergisi, 5(3), 641-652.
  • 8. Beaumont, R., Cordery, P., Funnell, M., Mears, S., James, L., Watson, P. (2017). Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine. Journal of Sports Sciences, 35(19), 1920-1927.
  • 9. Bell, D.G., Mclellan, T.M. (2002). Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers. Journal of Applied Physiology. 93(4), 1227-1234.
  • 10. Bottoms, L., Greenhalgh, A., Gregory, K. (2013). The effect of caffeine ingestion on skill maintenance and fatigue in epee fencers. Journal of Sports Sciences, 31(10), 1091-9.
  • 11. Burke, L.M. (2017). Practical issues in evidence-based use of performance supplements: supplement interactions, repeated use and individual responses. Sports Medicine, 47, 79-100.
  • 12. Cairns, S.P., Hing, W.A., Slack, J.R., Mills, R.G., Loiselle, D.S. (1997). Different effects of raised [K+] on membrane potential and contraction in mouse fast and slow-twitch muscle. American Journal of Physiology Cell Physiology, 273,598-611.
  • 13. Chia, J.S., Barrett, L.A., Chow, J.Y., Burns, S.F. (2017). Effects of caffeine supplementation on performance in ball games. Sports Medicine, 47(12), 2453-2471.
  • 14. Childs, E., Hohoff, C., Deckert, J., Xu, K., Badner, J., With, H. (2008). Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology, 33(12), 1694-1702.
  • 15. Christensen, P.M., Shirai, Y., Ritz, C., Nordborg, N.B. (2017). Caffeine and bicarbonate for speed. A meta-analysis of legal supplements potential for improving intense endurance exercise performance. Frontiers in Physiology, 8, 240.
  • 16. Christopher, L., Hendy, A., Vanderwesthuizen, D., Teo, W.P. (2018). The modulation of corticospinal excitability and inhibition following acute resistance exercise in males and females. European Journal of Sport Science, 18(7), 984-993.
  • 17. Clarke N, Baxter, H., Fajemilua, E., Jones, V., Oxford, S., Richardson, D.L., Wyatt, C., Mundy, P. (2016). Coffee and caffeine ingestion have little effect on repeated sprint cycling in relatively untrained males. Sports. 4, 45.
  • 18. Clarke, N.D., Richardson, D.L., Thie, J., Taylor, R. (2018). Coffee ingestion enhances 1-mile running race performance. Nutrients, 13, 789-794.
  • 19. Clarke, N.D., Kirwan, N.A., Richardson, D.L. (2019). Coffee ingestion improves 5 km cycling performance in men and women by a similar magnitude. Nutrients, 11, 2575.
  • 20. Clarke, N.D., Richardson, D.L. (2016). Effect of coffee and caffeine ingestion on resistance exercise performance. Journal of Strength and Conditioning Research. 30(10), 2892-2900.
  • 21. Cornelis, M.C. (2019). The impact of caffeine and coffee on human health. Nutrients, 11, 416.
  • 22. Cruz, R.S.D.O., De Aguiar, R.A., Turnes, T., Guglielmo, L.G.A., Beneke, R., Caputo, F. (2015). Caffeine affects time to exhaustion and substrate oxidation during cycling at maximal lactate steady state. Nutrients, 7, 5254-5264.
  • 23. Del Coso, J., Lara, B., Ruiz-Moreno, C., Salinero, J.J. (2019). Challenging the myth of non-response to the ergogenic effects of caffeine ingestion on exercise performance. Nutrients, 11, 732.
  • 24. Denoeud, F., Carretero-Paulet, L., Dereeper, A., Droc, G., Guyot, R., Pietrella, M., Aury, J.M. (2014). The coffee genome provides insight into the convergent evolution of caffeine biosynthesis. Science, 345(6201), 1181-1184.
  • 25. Doepker, C., Wikoff, D. (2018). Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Nutrients, 10(10), 1536.
  • 26. Duncan, M.J., Dobell, A.P., Caygill, C.L., Eyre, E., Tallis, J. (2019). The effect of acute caffeine ingestion on upper body anaerobic exercise and cognitive performance. European Journal of Sport Science, 19(1), 103-111.
  • 27. Dunican, I.C., Higgins, C.C., Jones, M.J., Clarke, M.W., Murray, K., Dawson, B., Caldwell, J.A., Halson, S.L.,
  • 28. Eastwood, P.R. (2018). Caffeine use in a super rugby game and its relationship to post – game sleep. European Journal of Sport Science, 18(4), 513-523.
  • 29. El Yacoubi, M., Ledent, C., Menard, J.F., Parmentier, M., Costentin, J., Vaugeois, J.M. (2000). The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A (2A) receptors. British Journal of Pharmacology, 129(7), 1465-1473.
  • 30. Ferre, S. (2016). Mechanisms of the psychostimulant effects of caffiene: implications for substance use disorder. Psychopharmacology, 233(10), 1963-1979.
  • 31. Ferreira, T.T., Farrias Da Silva, J.V., Bueno, N.B. (2020). Effects of caffeine supplementation on muscle endurance, maximum strength, and perceived exertion in adults submitted to strength training: a systematic review and meta-analyses. Critical Reviews in Food Science and Nutrition, 61(15), 2587-2600.
  • 32. Filip, A., Wilk, M., Krzytofik, M., Del Coso, J. (2020). Inconsistency in the ergogenic effect of caffeine in athletes who regularly consume caffeine: is it due to the disparity in the criteria that defines habitual caffeine intake?. Nutrients, 12, 1087.
  • 33. Filip-Stachnik, A., Wilk, M., Krzytofik, M., Lulinska, E., Tufano, J.J., Zajac, A., Stastny, P., Del Coso, J. (2021). The effects of different doses of caffeine on maximal strength and strength-endurance in women habituated to caffeine. Journal of International Society of Sports Nutrition, 18(1), 25.
  • 34. Foskett, A., Ali, A., Gant, N. (2009). Caffeine enhances cognitive function and skill performance during simulated soccer acitivity. International Journal of Sports Nutrition and Exercise Metabolism, 19(4), 410-423.
  • 35. Gonçalves, L.S., Painelli, V.S., Yamaguchi, G., Oliveira, L.F., Saunders, B., Silva, R.P., Maciel, E., Artioli, G.G., Roschel, H., Gualano, B. (2017). Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. Journal of Applied Physiology, 123(1), 213-220.
  • 36. Grgic J, Grgic I, Pickering C, Schoenfeld Bj, Bishop Dj, Pedisic Z (2019). Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. British Journal of Sports Medicine, 11: 681-688.
  • 37. Grgic, J., Mikulic, P. (2020). Acute effects of caffeine supplementation on resistance exercise, jumping, and wingate performance: no influence of habitual caffeine intake. European Journal of Sport Science, 21(8), 1165-1175.
  • 38. Graham, T.E. (2001). Caffeine and exercise: metabolism, endurance and performance. Sports medicine, 31(11), 785-807.
  • 39. Guest, N., Corey, P., Vesconi, J., El-Sohemy, A. (2018). Caffeine, CYP1A2 genotype, and endurance performance in athletes. Medicine and Science in Sport and Exercise, 50(8), 1570-1578.
  • 40. Guest, N.S., Vandusseldrop, T.A., Nelson, M.T., Grgic, J., Schoenfeld, B.J., Jenkinds, N.D.M., Arent, S.M., Antonio, J., Stout, J.R., Trexler, E.T., Smith-Ryan, A.E., Goldstein, E.R., Kalman, D.S., Campbell, B.I. (2021). International society of sport nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1.
  • 41. Hall, S., Desbrow, B., Anoopkumar-Dukie, S., Davey, A.K., Arora, D., Mcdermott, C., Grant, G.D. (2015). A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression. Food Research International, 76(3), 626-636.
  • 42. Hunter, S.K. (2016). The relevance of sex differences in performance fatigability. Medicine and Science in Sports and Exercise, 48(11), 2247-2256.
  • 43. Irwin, C., Desbrow, B., Ellis, A., O’Keeffe, B., Grant, G., Leveritt, M. (2011). Caffeine withdrawal and high-intensity endurance cycling performance. Journal of Sports Sciences. 29(5), 509-515.
  • 44. Jeukendrup, A.E. (2017). Periodized nutrition for athletes. Sports Medicine, 47, 51-63.
  • 45. Kaçoğlu, C. (2019). Adölesan kız hentbolcularda, düşük doz kahve tüketiminin anaerobik performansa akut etkileri. Türkiye Klinikleri Spor Bilimleri Dergisi, 11(3), 97-107.
  • 46. Kamimori, G.H., Karyekar, C.S., Otterstetter, R., Cox, D.S., Balkin, T.J., Belenky, G.L., Eddington, N.D. (2002). The rate of absortion and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy vounteers. International Journal of Pharmaceutics, 234(1-2), 159-167.
  • 47. Kara, Z., Taşkın, H., Erkmen, N., Baştürk, D. (2019). Kafein takviyesinin kısa süreli yüksek yoğunluklu egzersize etkisi: kafein alım zamanı. Spor ve Performans Araştırmaları Dergisi, 10(1), 31-43.
  • 48. Karayigit, R., Naderi, A., Akça, F., Gomez Da Cruz, C.J., Sarshin, A., Yasli, B.C., Ersöz, G., Kaviani, M. (2021). Effects of different doses of caffeinated coffee on muscular endurance, cognitive performance and cardiac autonomic modulation in caffeine naive female athletes. Nutrients, 13, 2.
  • 49. Lara, B., Ruiz-Moreno, C., Salinero, J.J., Del Coso, J. (2019). Time course of tolerance to the performance benefits of caffeine. Plos One, 14(1), e0210275.
  • 50. Lara, B., Salinero, J.J., Giraldez-Costos, V., Del Coso, J. (2021). Similar ergogenic effect of caffeine on anaerobic performance in men and women athletes. European Journal of Nutrition, online ahead of print.
  • 51. Liebherman, H.R., Tharion, W.J., Shukitt-Hale, B., Speckman, K.L., Tulley, R. (2002). Effects of caffeine, sleep loss and stress on cognitive performance and mood during U.S. Navy Seal training. Psychopharmacology, 164(3), 250-261.
  • 52. Magkos, F., Kavarous, S.T. (2005). Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Critical Reviews in Food Science and Nutrition. 45(7-8), 535-562.
  • 53. Marcil, M., Karelis, A.D., Peronet, F., Gardier, P.F. (2005). Glucose infusion attenuates fatigue without sparing glycogen in rat soleus muscle during prolonged electrical stimulation in situ. European Journal of Applied Physiology, 93(5-6), 569-574.
  • 54. Martins, G.L., Guilherme, J.P.L.F., Ferreira, L.H.B., Souza-Junior, T.P., Lancha, A.H. (2020). Caffeine and exercise performance: possible directions for definitive findings. Frontiers in Sports and Active Living, 2, 574854.
  • 55. Mattson, M.P. (2012). Evolutionary aspects of human exercise-born to run purposefully. Ageing Research Reviews, 11(3), 347-352.
  • 56. Maughan, R.J., Burke, L.M., Dvorak, J., Larson-Meyer D.E., Peeling, P., Philips, S.M. (2018). IOC consensus statement: dietary supplements and the high-performance athlete. International Journal of Sport Nutrition and Exercise Metabolism, 28(2), 104-125.
  • 57. Mclellan, T.M., Kamimori, G.H., Voss, D.M., Tate, C., Smith, S.J. (2007). Caffeine effects on physical and cognitive performance during sustained operations. Aviation Space Environmental Medicine, 78(9), 871-877.
  • 58. Mclellan, T.M., Caldwell, J.A., Liebherman, H.R. (2016). A review of caffeine’s effects of cognitive, physical and occupational performance. Nueroscience&Biobehavioral reviews, 71, 294-312.
  • 59. Mielgo-Ayuso, J., Marques-Jimenez, D., Refoyo, I., Del Coso, J., Leon-Guereno, P., Calleja-Gonzalez, J. (2019). Effect of caffeine supplementation on sports performance based on differences between sexes: a systematic review. Nutrients, 11, 2313.
  • 60. Mohr, M., Nielsen, J.J., Bangsbo, J. (2011). Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation. Journal of Applied Physiology, 111(5), 1372-1379.
  • 61. Ogawa, N., Ueki, H. (2007). Clinical importance of caffeine dependence and abuse. Psychiatry Clin Neurosci, 61(3), 263-268.
  • 62. Ou-Yang, D.S., Huang, S.L., Wang, W. (2000). Phenotypic polymorphism and gender-related differences of CYP1A2 activity in a Chinese population. British Journal of Clinical pharmacology, 49(2), 145-151.
  • 63. Ryan, E.J., Kim, C.H., Fickes, E.J., Williamson, M., Muller, M.D., Barkley, J.E. (2013). Caffeine gum and cycling performance: a timing study. Journal of Strength and Conditioning Research, 27(1), 259-264.
  • 64. Pallares, J.G., Fernandez-Elias, V.E., Ortega, J.F., Munoz, G., Munoz-Guerra J., Mora-Rodriguez, R. (2013). Neuromuscular responses to incremental caffeine doses: performance and side effects. Medicine and Science in Sport and Exercise, 45(11), 2184-2192.
  • 65. Pataky, M.W., Womack, C.J., Saunders, M.J., Goffe, J.L., D’Lugos, A.C., El-Sohemy, A. (2016). Caffeine and 3-km cycling performance effects of mouth rinsing, genotype, and time of day. Scandinavian Journal of Medicine and Science in Sports, 26(6), 613-619.
  • 66. Pickering, C., Grgic, J. (2019). Caffeine and exercise: what next?. Sports Medicine, 49(7), 1007-1030.
  • 67. Pickering, C., Grgic, J. (2021). A time and a place: a framework for caffeine periodization throughout the sporting year. Nutrition, 82, 111046.
  • 68. Pickering, C., & Kiely, J. (2019). Do non-responders to exercise exist—and if so, what should we do about them?. Sports Medicine, 49(1), 1-7.
  • 69. Pontifex, K.J., Wallman, K.E., Dawson, B.T., Goodman, C. (2010). Effects of caffeine on repeated sprint ability, reactive agility time, sleep and next day performance. Journal of Sports Medicine and Physical Fitness, 50(4), 455-464.
  • 70. Ruiz-Moreno, C., Lara, B., Gutierrez-Hellin, J., Gonzalez-Garcia, J., Del Coso, J. (2020). Time course and magnitude of tolerance to the ergogenic effect of caffeine on the second ventilatory threshold. Life, 10(12), 343.
  • 71. Ryan Ej, Kım Ch, Fıckes Ej, Wıllıamson M, Muller Md, Barkley Je (2013). Journal of Strength and Conditioning Research, 27: 259-264.
  • 72. Sabblah, S., Dizon, D., Bottoms, L. (2015). Sex differences on the acute effects of caffeine on maximal strength and muscular endurance. Comperative Exercise Physiology, 11(2), 89-94.
  • 73. Salinero, J., Jimenez-Ormeno, E., Romero-Moraleda, B., Giraldez-Costas, V., Baltazar-Martins, G., Del Coso, J. (2019). More research is necessary to establish the ergogenic effect of caffeine in female athletes. Nutrients, 11, 1600.
  • 74. Shen, JG, Brooks, M.B., Cincotta, J., Manjourides, J.D. (2019). Establishing a relationship between the effect of caffeine and duration of endurance athletic time trial events: a systematic review and meta-analysis. Journal of Science and Medicine in Sport, 22(2), 232-238.
  • 75. Skinner, T.L., Desbrow, B., Arapova, J., Schaumberg, M.A., Osborne, J., Grant, G.D., Aanookumar-Dukie, S., Leveritt, M.D. (2019). Women experience the same ergogenic response to caffeine as men. Medicine and Science in Sport and Exercise, 51(6), 1195-1202.
  • 76. Southward, K., Rurtherfurd-Markwick, K.J., Ali, A. (2018). The effect of acute caffeine ingestion on endurance performance: a systematic review and meta-analysis. Sports Medicine, 48(8), 1913-1928.
  • 77. Spriet, L.L. (2014). Exercise and sport performance with low doses of caffeine. Sports Medicine, Suppl 2, 175-184.
  • 78. Stuart, G.R., Hopkins, W.G., Cook, C., Cairns, S.P. (2005). Multiple effects of caffeine on simulated high-intensity team-sport performance. Medicine and Science in Sports and Exercise, 37(11), 1998-2005.
  • 79. Taylor, C., Higham, D., Close, G.L., Morton, J.P. (2011). The effect of adding caffeine to postexercise carbohydrate feeding on subsequent high-intensity interval-running capacity compared with carbohydrate alone. International Journal of Sport Sutrition and Exercise Metabolism, 21(5), 410-416.
  • 80. Tepper, J.M., Wilson, C.J., Koös, T. (2008). Feedforward and feedback inhibition in neostriatal GABAergic spiny neurons. Brain Research Reviews, 58(2), 272-281.
  • 81. Thibault, V., Guillaume, M., Berthelot, G., El Helou, N., Schaal, J., Quinquis, L., Nassif, H., Tafflet, M., Escolano, S., Hermine, O. (2010). Women and men in sport performance: the gender gap has not evolved since 1983. Journal of Sports Science and Medicine, 9(2), 214-223.
  • 82. Trexler, E.T., Smith-Ryan, A.E., Roelofs, E.J., Hirsch, K.R., Mock, M.G. (2015). Effects of coffee and caffeine anhydrous on strength and sprint performance. European Journal of Sport Science. 16(6), 702-710.
  • 83. Ulucan, K., Sercan, C., Eken B.F., Ulgut, D., Erel, S. (2016). Spor genetiği ve ace gen ilişkisi. İnönü Üniversitesi Beden Eğitimi ve Spor Bilimleri Dergisi, 3(2), 26-34.
  • 84. Warren, G.L., Park, N.D., Maresca, R.D., Mckibans, K.I., Millard-Stafford, M.L. (2010). Effect of caffiene ingestioon muscular strength and endurance: a meta-alalysis. Medicine and Science in Sport and Science. 42(7), 1375-1387.
  • 85. Wilk, M., Filip, A., Krzsytofik, M., Maszczy, A., Zajac, A. (2019). The acute effect of various doses of caffeine on power output and velocity during the bench press exercise among athletes habitually using caffeine. Nutrients, 11, 1465.
  • 86. Womack, C.J., Saunders, M.J., Bechtel, M.K., Bolton, D.J., Martin, M., Luden, N.D. (2012). The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. Journal of International Society of Sport Nutrition, 9(1), 438-452.
  • 87. Van Thuyne, W., Delbeke, F.T. (2006). Distribution of caffeine levels in urine in different sports in relation to doping control before and after the removal of caffeine from the WADA doping list. International Journal of Sports Medicine, 27(9), 745-750.
  • 88. Yang, C., Franciosi, S., Brown, R.E. (2013). Adenosine inhibits the excitatory synaptic inputs to basal forebrain cholinergic, GABAergic, and parvalbumin neurons in mice. Frontiers in Neurology, 4, 77.
  • 89. Zhan, B., Liu, Y., Wang Xiaochun, W., Deng, Y., Zheng, X. (2020). Cognition and brain activation in response to various doses of caffeine: a near-infrared spectroscopy study. Frontiers in Psychology, 11, 1393.
There are 89 citations in total.

Details

Primary Language English
Subjects Sport and Exercise Nutrition
Journal Section Reviews
Authors

Raci Karayiğit

Muhammed Uygar Sertkaya

Publication Date December 5, 2022
Published in Issue Year 2022 Volume: 1 Issue: 1

Cite

APA Karayiğit, R., & Sertkaya, M. U. (2022). Effects of Caffeine on Physical and Cognitive Performance: A Review. Performance Analysis in Sport and Exercise, 1(1), 1-20.
AMA Karayiğit R, Sertkaya MU. Effects of Caffeine on Physical and Cognitive Performance: A Review. PASE. December 2022;1(1):1-20.
Chicago Karayiğit, Raci, and Muhammed Uygar Sertkaya. “Effects of Caffeine on Physical and Cognitive Performance: A Review”. Performance Analysis in Sport and Exercise 1, no. 1 (December 2022): 1-20.
EndNote Karayiğit R, Sertkaya MU (December 1, 2022) Effects of Caffeine on Physical and Cognitive Performance: A Review. Performance Analysis in Sport and Exercise 1 1 1–20.
IEEE R. Karayiğit and M. U. Sertkaya, “Effects of Caffeine on Physical and Cognitive Performance: A Review”, PASE, vol. 1, no. 1, pp. 1–20, 2022.
ISNAD Karayiğit, Raci - Sertkaya, Muhammed Uygar. “Effects of Caffeine on Physical and Cognitive Performance: A Review”. Performance Analysis in Sport and Exercise 1/1 (December 2022), 1-20.
JAMA Karayiğit R, Sertkaya MU. Effects of Caffeine on Physical and Cognitive Performance: A Review. PASE. 2022;1:1–20.
MLA Karayiğit, Raci and Muhammed Uygar Sertkaya. “Effects of Caffeine on Physical and Cognitive Performance: A Review”. Performance Analysis in Sport and Exercise, vol. 1, no. 1, 2022, pp. 1-20.
Vancouver Karayiğit R, Sertkaya MU. Effects of Caffeine on Physical and Cognitive Performance: A Review. PASE. 2022;1(1):1-20.
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